Kun Dai

Peptides play a crucial role in biological systems and industrial applications, underpinning a wide array of vital functions. However, the exact mechanisms by which peptides formed on early Earth—without the aid of ATP, RNA, or enzymes—remain unclear. In this research, we will convert aminoacyl phosphate esters into building blocks that construct non-equilibrium droplets, who plays a role as protocell, facilitating peptide synthesis within these microenvironments. Furthermore, given the significant pollution and high costs associated with traditional peptide synthesis methods, our approach aims to develop a sustainable approach to peptide synthesis within droplets in drop of water, avoiding harmful solvents and minimizing chemical waste. This research aims to build a bridge from fundamental research to practical applications.